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Abstract #2935

Repeatability of 13C-MRS for absolute glycogen content quantification in the human liver and skeletal muscle at 7T

Pandichelvam Veeraiah1,2, Cas J Fuchs3, Rick Voncken1, Kim Brouwers1,2, Job van den Hurk1,4, Joachim E Wildberger2,5, Peter E Thelwall6,7, Jeanine J Prompers1,2,3, and Luc J. C van Loon3
1Scannexus (Ultra-High Field MRI Center), Maastricht, Netherlands, 2Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), Maastricht, Netherlands, 3Department of Human Biology, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands, 4Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, 5Cardiovascular Research Institute Maastricht, (CARIM), Maastricht University, Maastricht, Netherlands, 6Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, 7Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom

Synopsis

Keywords: Spectroscopy, Liver, 13C-MRS, glycogen, Ultra-high-field, X-nuclei-MRS, muscle, liver

Motivation: The extent of methodological variability between repeated measures of tissue glycogen content by 13C-MRS determines the detection limit of actual changes in glycogen due to interventions/disease progression within the same individuals.

Goal(s): To assess repeatability of 13C-MRS measurements for glycogen quantification in the human liver and skeletal muscle at 7T.

Approach: Absolute glycogen concentrations were determined by applying 13C-MRS at 7T in 12 young healthy volunteers on three different time points, in both liver and muscle.

Results: Repeatability of 13C-MRS at 7T for absolute glycogen quantification was good in both liver and muscle tissue.

Impact: 13C-MRS at 7T showed good repeatability for absolute glycogen quantification in human liver and muscle, which is promising for its clinical applicability to measure intervention/disease related changes in glycogen content.

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Abstract

Keywords