Keywords: Spectroscopy, Brain
Motivation: Preclinical 2D 1H-FID-MRSI has offered great and reproducible metabolite maps on the rat brain. The technique can be extended for whole-brain acquisition for richer information.
Goal(s): Implement and test the feasibility of 3D and multislice 1H-FID-MRSI for rat brain metabolite mapping.
Approach: Using optimized compressed sensing schemes to accelerate 3D and multislice acquisition, for volumetric acquisition in the rat brain.
Results: Both methodologies have produced great through-plane coverage and concentration estimates are in line with 2D FID-MRSI measurements.
Impact: 3D and multislice 1H-FID-MRSI can offer greater insight in the rat brain metabolism, enabling finer description of neurodegenerative diseases within preclinical models, such as the bile duct ligation rat model for hepatic encephalopathy.
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