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Abstract #2938

First implementation of fast 1H 3D-FID-MRSI on the rodent brain at 9.4T for metabolite mapping

Brayan Alves1,2, Thanh Phong Lê1,2, Bernhard Strasser3, Wolfgang Bogner3,4, Bernard Lanz1,2, and Cristina Cudalbu1,2
1Centre d'Imagerie Biomedical - CIBM, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 3Department of Radiology, MR Center of Excellence, Medical University Vienna, Vienna, Austria, 4Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria

Synopsis

Keywords: Spectroscopy, Brain

Motivation: Preclinical 2D 1H-FID-MRSI has offered great and reproducible metabolite maps on the rat brain. The technique can be extended for whole-brain acquisition for richer information.

Goal(s): Implement and test the feasibility of 3D and multislice 1H-FID-MRSI for rat brain metabolite mapping.

Approach: Using optimized compressed sensing schemes to accelerate 3D and multislice acquisition, for volumetric acquisition in the rat brain.

Results: Both methodologies have produced great through-plane coverage and concentration estimates are in line with 2D FID-MRSI measurements.

Impact: 3D and multislice 1H-FID-MRSI can offer greater insight in the rat brain metabolism, enabling finer description of neurodegenerative diseases within preclinical models, such as the bile duct ligation rat model for hepatic encephalopathy.

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