Abstract #2945

An initial report of quantitative analysis of segmented whole-brain MRSI in epilepsy

Haniye Shayeste^1,2, Stefanie Chambers^1,2, Philipp Lazen^1,2, Matthias Tomschik¹, Jonathan Wais¹, Gregor Kasprian³, Lukas Haider³, Leo Hofer³, Christoph Baumgartner⁴, Johannes Koren⁴, Martha Feucht⁵, Christian Dorfer¹, Ekaterina Pataraia⁶, Wolfgang Bogner^2,7, Siegfried Trattnig^2,7, Karl Rössler^1,7, and Gilbert Hangel^1,2,7,8

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ²MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁴Department of Neurology, Krankenhaus Hietzing, Vienna, Austria, ⁵5Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, ⁶Department of Neurology, Medical University of Vienna, Vienna, Austria, ⁷Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria, ⁸Functional Imaging Laboratory, Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

Synopsis

Keywords: Spectroscopy, Spectroscopy, Epilepsy, MRI segmentation

Motivation: Our motivation is to study neurochemical changes using Magnetic Resonance Spectroscopic Imaging (MRSI) in MR-negative patients with epilepsy whose structural MRI fails to reveal the Seizure Onset Zone (SOZ).

Goal(s): Regionally analyzing the MRSI maps for different metabolites in the main lobes of the brain.

Approach: Finding the median of Concentration Estimates (CE), we defined the highest relative difference between left and right hemisphere to highlight asymmetries which we compared with the clinically defined SOZs.

Results: We found a relationship between neurochemical asymmetries and SOZ in 7 out of 10 patients.

Impact: For the first time, we established regional concentration estimates of neurochemicals in epilepsy patients using 7T MRSI. Detecting abnormal concentrations could improve the diagnostic performance in MR-negative patients.

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