Abstract #2950

Feasibility of MR Fingerprinting in a Longitudinal Study of Knee Articular Cartilage

Diana Sitarcikova¹, Veronika Janacova¹, Barbara Hristoska¹, Malina Gologan¹, Martijn A. Cloos², Pavol Szomolanyi^1,3, Siegfried Trattnig^1,4,5,6, and Vladimir Juras¹

¹Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, Austria, ²Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, ³Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁴CD Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria, ⁵Austrian Cluster for Tissue Regeneration, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria, ⁶Institute for Clinical Molecular MRI in the Musculoskeletal System, Karl Landsteiner Society, Vienna, Austria

Synopsis

Keywords: Cartilage, Cartilage, T2 mapping, MR Fingerprinting, MSK, Longitudinal study

Motivation: MRF is a rapid and robust novel method for MR multi-parametric mapping.

Goal(s): To evaluate the feasibility of MRF T₂ mapping in a longitudinal study of the knee articular cartilage.

Approach: 26 patients with at least one focal cartilage lesion were recruited for two knee MRI examinations, including MRF and CPMG T₂ mapping, one year apart. The change in T₂ over the two time-points was analyzed.

Results: A change in T₂ values from baseline to one-year follow-up was observed in lesion segments, and the change measured by MRF and CPMG was highly correlated (r = 0.858, p = 0.001).

Impact: This preliminary study suggests that MRF T₂ mapping is feasible in longitudinal studies and can reliably capture changes in T₂ over time resulting from pathophysiological changes in knee articular cartilage. This preliminary study will be extended to larger population.

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