Abstract #2977

Relationship of glymphatic markers, neurotransmitters with cognitive performance in cerebral small vessel disease: A novel investigation

Changjun Ma^1,2,3, Ailian Liu⁴, Xiulin Wang^2,3, Fengyu Cong^1,5, Liangjie Lin⁶, Peng Sun⁶, Ying Li^2,3, and Jing Liu^2,3

¹Faculty of Medicine, Dalian University of Technology, Dalian, China, ²Stem Cell Clinical Research Center, National Joint Engineering Laboratory, Regenerative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China, ³Dalian Innovation Institute of Stem Cell and Precision Medicine, Dalian, China, ⁴Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China, ⁵Faculty of Information Technology, University of Jyväskylä, Jyväskylä, Finland, ⁶Philips Health Technology (China) Co., Ltd., Beijing, China

Synopsis

Keywords: Dementia, Brain, MR, glymphatic markers, neurotransmitter

Motivation: glymphatic system activity is critical for maintaining brain fluid homeostasis throughout the life cycle, and its dysfunction is closely associated with altered cognitive function in patients with CSVD

Goal(s): We aim to investigate the differences of glymphatic markers and metabolite levels between three groups, following HC group, CSVD-NC group, and CSVD-MCI group

Approach: The DTI-ALPS index, the burden of EPVS, ChP volume and FW fraction were calculated to reflect glymphatic function.

Results: The DTI-ALPS index and BG_PVS reminded significant differences between HC and CSVD-MCI groups. For the GABA+ level in mPFC, there was a difference between the HC and the CSVD-MCI groups.

Impact: Our study provided evidence that both the GABA+ level and CSVD image maskers were associated with glymphatic dysfunction in CSVD patients

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