Abstract #2979

Investigating the Impact of Presurgical White Matter Microstructure on Surgical Outcomes of VIM-DBS in Essential Tremor

Sohae Chung^1,2, Ha Neul Song³, Yvonne W. Lui^1,2, Brian H. Kopell⁴, and Ki Sueng Choi³

¹Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴3Center for Neuromodulation, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Keywords: Other Neurodegeneration, Brain, Essential Tremor, Deep Brain Stimulation, White Matter Integrity

Motivation: Identifying biomarkers that can predict outcomes of deep brain stimulation (DBS) in essential tremor (ET) patients is essential for personalizing surgical plans and maximizing treatment effectiveness.

Goal(s): Our goal was to identify in vivo presurgical biomarkers that could predict clinical outcomes in ET patients following DBS, using diffusion MRI.

Approach: Presurgical diffusion MRI was performed on 11 ET patients. Spearman correlation analysis was applied to examine associations between preoperative WM integrity and DBS outcomes, as measured by TETRAS.

Results: Significant correlations were found between fractional anisotropy and TETRAS scores in key WM regions linked to tremor, highlighting potential predictive markers for DBS outcomes.

Impact: Our findings highlight presurgical diffusion imaging as a sensitive predictor of DBS outcomes in ET patients, offering potential quantitative biomarkers to guide personalized surgical planning and enhance treatment outcomes.

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