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Abstract #2983

MRI imaging of myelin and iron in Huntington’s Disease

Jiyo Srinivasan Athertya1, James Lo1,2, Soo Hyun Shin1, Krisha Bagga3, Yajun Ma1, Haiying Tang4, Graeme M Bydder1, Jody Corey-Bloom3, and Jiang Du1,2,5
1Department of Radiology, UCSD, San Diego, CA, United States, 2Department of Bioengineering, UCSD, San Diego, CA, United States, 3Department of Neuroscience, UCSD, San Diego, CA, United States, 44. CHDI Management, the company that manages the scientific activities of CHDI Foundation, Princeton, NJ, United States, 5Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States

Synopsis

Keywords: Other Neurodegeneration, Quantitative Susceptibility mapping, UTE imaging, Huntington's Disease

Motivation: Huntington’s disease (HD) is characterized by myelin damage and iron accumulation. Robust detection of myelin and iron is critical.

Goal(s): To apply a series of MRI techniques to detect myelin and iron changes in HD.

Approach: A 3D Short TR Adiabatic Inversion Recovery UTE (STAIR-UTE) sequence for Myelin Proton Fraction (MPF) mapping, UTE Quantitative Susceptibility Mapping (UTE-QSM) sequence for iron mapping, divided Subtracted Inversion Recovery (dSIR) sequence for morphological imaging, and synthetic MRI have been applied to HD (n=7) and control (n=7) population.

Results: People with HD show significant myelin loss in white matter and iron accumulation in gray matter over control subjects.

Impact: The STAIR-UTE, UTE-QSM and dSIR techniques can detect myelin loss, iron accumulation, and morphological changes in HD, respectively, and may help with early diagnosis and treatment monitoring of HD.

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Keywords