Abstract #2986

1H-MRSI of the Deep Gray Matter Nuclei in Patients With Amyotrophic Lateral Sclerosis

Arda Canbaş¹, Gökçe Hale Hatay², Meryem Torlak¹, Barış İşak³, Alpay Özcan⁴, Dilaver Kaya⁵, Alp Dinçer ^6,7,8, and Esin Öztürk Işık^1,7

¹Institute of Biomedical Engineering, Boğaziçi University, İstanbul, Turkey, ²Siemens Healthineers, İstanbul, Turkey, ³Department of Neurology, Marmara University, İstanbul, Turkey, ⁴Department of Electrical and Electronics Engineering, Boğaziçi University, İstanbul, Turkey, ⁵Department of Neurology, Acıbadem University, İstanbul, Turkey, ⁶Department of Radiology, Acıbadem University, İstanbul, Turkey, ⁷Brain Tumor Research Group, Acıbadem University, İstanbul, Turkey, ⁸Neuroradiological Application and Research Center, Acıbadem University, İstanbul, Turkey

Synopsis

Keywords: Other Neurodegeneration, Neurodegeneration

Motivation: There is a need to define early biomarkers of amyotrophic lateral sclerosis (ALS) by investigating metabolic differences in patients with distinct regional onsets.

Goal(s): Identify specific metabolic differences among ALS patients based on their regional and limb onsets.

Approach: 1H-MRSI data from deep gray matter nuclei of 29 ALS patients were quantified using LCModel and compared between different onset groups.

Results: Lumbosacral onset patients showed higher tNAA/tCr and Tau/tCr in white matter than cervical onset patients. ALS patients had elevated Glu/tCr in the left putamen for the left onset and in the right caudate for the right onset.

Impact: This study demonstrated that alterations in tNAA/tCr, Tau/tCr, and Glu/tCr ratios could enhance the understanding of ALS pathophysiology in distinct regional and limb onset groups and potentially contribute to future treatment planning.

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