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Abstract #2994

Blood-brain barrier water permeability in relation to Alzheimer’s Disease and age-related vascular damage

Beatriz E. Padrela1, Sandra Tecelão2, Mario E. Tranfa1, Oliver Geier3, Markus H Sneve4, David E. Vallez Garcia1, Amnah Mahroo5, Lene Pålhaugen2, Bjørn-Eivind Kirsebom6, Klaus Eickel5, David L. Thomas7, Atle Bjørnerud8, Anders M. Fjell4, Kristine B. Walhovd4, Frederik E. Barkhof1,9, Per Selnes2, Matthias Günther5, Jan Petr10, Tormod Fladby2, and Henk J.M.M. Mutsaerts1
1Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 2Department of Neurology, Akershus University Hospital, Oslo, Norway, 3Department of Physics and Computational Radiology, Oslo University Hospital, Oslo, Norway, 4Department of Psychology, Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway, 5Fraunhofer-Institute for Digital Medicine MEVIS, Bremen, Germany, 6Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway, 7Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 8Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 9Queen Square Institute of Neurology and Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, 10Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany

Synopsis

Keywords: Alzheimer's Disease, Arterial spin labelling, Blood-brain barrier, Biomarkers

Motivation: Blood-brain barrier (BBB) permeability changes may be implicated in both Alzheimer’s Disease (AD) and cerebrovascular aging.

Goal(s): To investigate if the exchange time (Tex) of blood water across the BBB is associated with AD and vascular parameters.

Approach: We measured Tex with a multi-echo arterial spin labeling MRI sequence in 137 adults older than 50 years and studied its association with cognitive stage, amyloid status, and vascular parameters (blood pressure and FLAIR white matter hyperintensities).

Results: BBB Tex was lower in MCI patients than in healthy controls. Tex was also lwoer in amyloid positive participants. Tex was not associated with the vascular parameters.

Impact: Our results suggest that multi-TE ASL MRI BBB water permeability can be used as an early imaging biomarker of AD pathophysiology.

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Abstract

Keywords