Abstract #2996

An 11-minute ARIA brain protocol for 0.6T

Martijn Nagtegaal¹, Yiming Dong¹, Navid Jabarimani¹, Ece Ercan², Andrew Webb¹, Peter Börnert^1,3, Mark A. van Buchem^1,4, and Matthias J.P. van Osch¹

¹C.J. Gorter MRI Center, Radiology, Leiden University Medical Center, Leiden, Netherlands, ²MR Clinical Science, Philips Healthcare, Best, Netherlands, ³Philips Research, Hamburg, Germany, ⁴Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: Anti-amyloid immunotherapy on MCI and dementia patients requires monitoring of amyloid-Related Imaging Abnormalities (ARIA) through several MRI scans

Goal(s): To assess the feasibility of a comprehensive ARIA brain protocol at 0.6T.

Approach: A brain protocol in line with the ASNR ARIA guidelines was developed and tested in 6 healthy subjects.

Results: Diagnostic quality can be achieved with an MRI examination time of 11 minutes.

Impact: This study shows that 0.6T MRI can provide neuro MRI scans in line with ARIA guidelines of diagnostic quality in a scan time comparable to standardized 1.5T ARIA monitoring protocols.

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