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Abstract #3001

The evaluation of patterns in gray matter damage during the development of Alzheimer's disease by using VBM analysis

Shuai Lin1, Wei Wang1, and Jianxiu Lian2
1MRI, First Affiliated Hospital of Harbin Medical University, harbin, China, 2Philips Healthcare, BeiJing, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. The pattern of damage in memory circuits and its relationship to pathological markers remain unclear.

Goal(s): The goal is to evaluate the transmission pattern of AD characteristic pathology in memory circuits based on AD cohort population in vivo.

Approach: In this study, AD continuum was constructed to model the pathological development of AD, and VBM was used to analyze the damage pattern of brain gray matter structure.

Results: Hippocampal volume atrophy was identified as occurring first with the aggravation of AD pathological changes, and the degree of damage increased as AD progressed.

Impact: VBM analysis can reveal the morphological changes of gray matter across the AD continuum, thereby revealing the temporal and spatial progression of AD pathological changes.

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