Abstract #3003

Quantification of Amyloid in the Piriform Cortex in Alzheimer’s and Parkinson’s Disease using PET-MR

Hossein Moein Taghavi¹, Mahta Karimpoor¹, Eric van Staalduinen¹, Christina B Young², Marios Georgiadis¹, Mackenzie Carlson², America Romero², Alexandra Trelle², Hillary Vossler², Maya Yutsis², Jarrett Rosenberg¹, Guido A Davidzon¹, Greg Zaharchuk¹, Kathleen L Poston², Anthony D Wagner^3,4, Victor W Henderson^2,5, Elizabeth Mormino^2,3, and Michael Zeineh¹

¹Department of Radiology, Stanford University School of Medicine, Stanford, CA, United States, ²Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States, ³Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA, United States, ⁴Department of Psychology, Stanford University, Stanford, CA, United States, ⁵Department of Epidemiology and Population Health, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: Olfactory dysfunction may be an early indicator of Alzheimer’s disease (AD), but it remains unclear whether amyloid pathology in AD affects the primary olfactory piriform cortex.

Goal(s): To compare piriform cortex uptake to the adjacent medial temporal lobe across the progression of AD pathology using amyloid and tau PET-MR.

Approach: Using ¹⁸F-Florbetaben/PI-2620 PET-MR, we computed piriform and medial temporal amyloid/tau uptake in AD, mild cognitive impairment, amyloid negative/positive controls, and Parkinson’s disease (PD).

Results: Piriform amyloid was positively associated with increasing disease status. Amyloid and tau uptake were positively correlated, while amyloid and memory scores were negatively correlated.

Impact: We show amyloid uptake in the piriform cortex as well as other medial temporal regions, including the entorhinal-perirhinal cortices. These results further enrich the scientific understanding of the role of the piriform cortex in the progression of early AD.

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