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Abstract #3009

Measurement of Pulmonary Hematocrit Using Oscillation of Hyperpolarized129Xe MR Signals in Blood

Xiaoling Liu1,2, Haidong Li1,2, Hongchuang Li1,2, Ming Zhang1,2, Yu Zheng1, Xiuchao Zhao1,2, Yeqing Han1,2, Fumin Guo1, and Xin Zhou1,2
1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Wuhan, China, 2University of Chinese Academy of Sciences, Beijing, China

Synopsis

Keywords: Biomarkers, biomarkers, hematocrit, hyperpolarized Xenon MR, lung, anemia, gas exchange function

Motivation: Accurate, non-invasive pulmonary hematocrit (Hct) assessment is crucial for detecting lung function abnormalities but remains challenging with existing methods like blood tests and CSSR.

Goal(s): This study aims to establish a faster, non-invasive approach to measure pulmonary Hct using hyperpolarized 129Xe MR signal oscillations.

Approach: We analyzed cardiac-induced oscillations in 129Xe MR signals from red blood cells and tissue/plasma compartments in rat models to estimate Hct and compared results with CSSR and blood tests.

Results: Pulmonary Hct values strongly correlated with traditional measurements, demonstrating the method’s sensitivity to blood composition changes in anemia models.

Impact: This novel approach for pulmonary Hct assessment enables non-invasive measurements of lung blood composition, providing new possibilities for early lung disease detection. It enables accurate Hct measurements in small pulmonary vessels, potentially refining disease diagnosis and progression monitoring.

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