Abstract #3015

Development and Evaluation of ASL Imaging Protocol and Methods for Studies of Ischemic Events in the Swine Brain

Xiufeng Li¹, Anja Metzger^2,3, Johanna C. Moore ^3,4, Pouria John Pourzand ^2,3, Hamza Hai³, Hamza John Farooq ¹, Christophe John Lenglet ¹, Bayert John Salverda³, Mithun Suresh⁵, Keith G. Lurie^2,3, and Gregory J Metzger¹

¹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²University of Minnesota, Minneapolis, MN, United States, ³Hennepin Healthcare Research Institute, Minneapolis, MN, United States, ⁴Hennepin County Medical Center, Minneapolis, MN, United States, ⁵CentraCare-St. Cloud Hospital, Saint Cloud, MN, United States

Synopsis

Keywords: Biology, Models, Methods, Preclinical, ASL, Perfusion, Reproducibility, T1 Mapping

Motivation: To facilitate research studies benefiting from longitudinal measures of perfusion in the swine brain.

Goal(s): Implement a perfusion study protocol and evaluate the reproducibility and feasibility of SMS/MB-EPI pseudo-continuous arterial spin labeling (PCASL) in a swine model.

Approach: In vivo perfusion studies were performed at 3T to assess the reproducibility and the feasibility of PCASL imaging. Additional acquisitions included high resolution anatomic imaging and T₁ mapping to facilitate segmentation and registration.

Results: Our results suggest that PCASL imaging is a promising approach to assess brain perfusion changes in the study of ischemic events in the swine model.

Impact: Development of non-contrast enhanced arterial spin labeling methods for swine brain perfusion imaging will provide pre-clinical researchers a valuable tool to assess and monitor brain perfusion changes following injury or interventions.

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