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Abstract #3018

Detecting white adipose tissue browning in mice with in vivo R2* mapping at 9.4T MRI

QiaoLing Zhong1, Hongsheng Liu1, Yanqiu Feng2, Xiuwei Jiao3, Yuanbo Yang4, Yongzhou Xu5, Zimeng Cai4, Zaiyi Liu4, and Kejia Cai6,7
1Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China, 2School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 3Department of Radiology,, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China, 4Department of Radiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China, 5Philips Healthcare, Guangzhou, China, 6Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, 7Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, United States

Synopsis

Keywords: Small Animals, Animals

Motivation: The research and application of white adipose tissue (WAT) browning, a promising strategy to combat obesity, are limited by the lack of sensitive and non-invasive imaging methods.

Goal(s): To explore the potential of R2* as an imaging biomarker for WAT browning.

Approach: We investigated WAT browning induced by long-term CL316,243 stimulation in mice and quantified the changes in R2*, fat-water fraction (FWF), UCP1 expression, and iron content.

Results: We observed increased R2* and decreased FWF during WAT browning. The UCP1 expression of WAT was strongly correlated with R2* and FWF, and the R2* was highly correlated with the ex vivo iron content.

Impact: We demonstrated R2* may be a more valuable and specific biomarker, especially specific circumstances involving iron-regulated pathways and interventions for WAT browning, which may offer a novel strategy for monitoring and regulating WAT metabolism to combat obesity and metabolic diseases.

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Abstract

Keywords