Abstract #3022

Monitoring early response to low-dose Radiation Therapy with UTE Diffuse and Dense fibrosis imaging in swine and cervical cancer patients

Khadija Sheikh¹, Kai Ding¹, Bruce Daniel², Clifford Weiss³, Arun Kamireddy ³, Daniel Song¹, Junghoon Lee¹, Ravi Seethamraju⁴, Thomas Benkert⁵, Junichi Tokuda⁶, Kathleen Gabrielson⁷, Himanshu Bhat⁴, Victoria Croog¹, Akila Viswanathan¹, and Ehud J Schmidt^1,8

¹Radiation Oncology, Johns Hopkins Medicine, Baltimore, MD, United States, ²Radiology, Stanford University, Palo Alto, CA, United States, ³Radiology, Johns Hopkins Medicine, Baltimore, MD, United States, ⁴Siemens Healthineers, Boston, MA, United States, ⁵Siemens Healthineers, Erlangen, Germany, ⁶Radiology, Massachusetts General Brigham, Boston, MA, United States, ⁷Molecular and Comparative Pathobiology, Johns Hopkins Medicine, Baltimore, MD, United States, ⁸Medicine (Cardiology), Johns Hopkins Medicine, Baltimore, MD, United States

Synopsis

Keywords: Cancer, Cancer

Motivation: We demonstrated diffuse-fibrosis and dense-fibrosis imaging during and post-radiation therapy (RT) in cervical-cancer and prostate-cancer patients, using non-contrast and Late-Gadolinium-Enhanced IR-UTE.

Goal(s): We now focus on early response to low radiation dose, validating that fibrosis imaging is an early marker allowing for changing dose-distribution during treatment to improve tumor response

Approach: We compare hypoxic and normoxic swine fibrosis 1-3 weeks post-10Gy radiation, as hypoxia reduces RT response, and show histology-slides illustrating differences between diffuse- and dense-fibrosis. We also show weekly fibrosis imaging during 0-22Gy radiotherapy, in cervical-cancer patients.

Results: Diffuse-fibrosis&Dense-fibrosis increase after 5Gy radiation and track tumor-shrinkage, serving as markers of tumor response.

Impact: Tumor response can differ widely between patients, even when receiving the same RT. If the response can be predicted early-on, treatment can be modified to improve outcome. We show that fibrosis imaging serves as a sensitive early marker of radiation-response.

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