Abstract #3028

Intravoxel Incoherent Motion (IVIM) MRI of the Human Pancreas Detects Altered Glucose-Stimulated Pancreas Perfusion in Type 1 Diabetes

Chengyue Wu^1,2,3,4, Ingrid Harris⁵, Avni Mody⁶, Pratima Kumar⁶, and Jack Virostko^5,7,8,9

¹Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, ²Breast Imaging, MD Anderson Cancer Center, Houston, TX, United States, ³Biostatistics, MD Anderson Cancer Center, Houston, TX, United States, ⁴Institute for Data Science, MD Anderson Cancer Center, Houston, TX, United States, ⁵Diagnostic Medicine, University of Texas at Austin, Austin, TX, United States, ⁶Internal Medicine, University of Texas at Austin, Austin, TX, United States, ⁷Oncology, University of Texas at Austin, Austin, TX, United States, ⁸Oden Institute, University of Texas at Austin, Austin, TX, United States, ⁹Livestrong Cancer Institutes, University of Texas at Austin, Austin, TX, United States

Synopsis

Keywords: Pancreas, Diabetes

Motivation: Monitoring of the pancreatic islet can help predict participants at risk for developing diabetes and facilitate development of islet-directed therapies.

Goal(s): This study employed IVIM to detect the vascularity of pancreatic islets and their response to glucose.

Approach: We imaged pancreas perfusion in 14 control participants with no pancreas pathology and 2 participants with type 1 diabetes. Pancreas perfusion was imaged dynamically after oral ingestion of a 30 g glucose gel.

Results: We found that pancreas perfusion increased ~14% in response to glucose ingestion in control participants, but perfusion was delayed and transient in participants with type 1 diabetes.

Impact: MRI of pancreas perfusion can improve our understanding of vasculature dysfunction in diabetes. Studies in larger populations of participants with diabetes and those at risk for diabetes may help us better predict disease onset and evaluate novel therapies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.