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Abstract #3037

Multiparametric MRI evaluation of early renal fibrosis and therapeutic effect of asiatic acid in an experimental rat model

Xueting Wang1, Lihua Chen1, Yujun Lu1, Weijing Yan1, Shuangshuang Xie1, Jipan Xu1, Zhandong Hu1, Jinxia Zhu2, Bernd Kuehn2, Robert Grimm2, and Wen Shen1
1Tianjin First Central Hospital, Tianjin, China, 2Siemens Healthcare, Beijing, China

Synopsis

Keywords: fMRI Analysis, Animals, Multi-parametric MRI, early renal fibrosis, asiatic acid

Motivation: Noninvasive MRI techniques such as ASL, DKI and T1 imaging have not been adequately validated in detecting kidney injury and renal fibrosis.

Goal(s): To prove that multiparameter MRI can evaluate the degree of renal fibrosis and the therapeutic effect of treatment.

Approach: MRI, immunohistochemical, and pathological examinations were performed for the renal injury model group and the treatment group.

Results: Multiparameter MRI can dynamically evaluate renal fibrosis and therapeutic efficacy of treatment. The method can detect changes in renal structure, function, internal molecular metabolism, and post-treatment efficacy in rats with renal fibrosis.

Impact: Multiparametric MRI has the potential to noninvasively detect early microstructural changes in patients with CKD before a significant renal functional decline and can determine proof of activity for evaluating therapies.

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