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Abstract #3041

Subclinical dysfunction for overweight people with and without type 2 diabetes using cardiovascular magnetic resonance (CMR) and 4D flow CMR

Sungho Park1, Erin Englund1, Takashi Fujiwara1, Danny Enge1, Michal Schäfer2, Brian Fonseca3, Kendall Hunter4, Judith G. Regensteiner5,6, Jane EB Reusch7,8, and Alex J Barker1,4
1Department of Radiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2Division of Cardiothoracic Surgery, University of Utah Health, Salt Lake City, UT, United States, 3Department of Pediatrics, Section of Pediatric Cardiology, Children’s Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 4Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 5Department of Medicine, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, United States, 6Ludeman Family Center for Women’s Health Research, Aurora, CO, United States, 7Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 8Rocky Mountain Regional Veterans Administration Medical Center (VAMC), Aurora, CO, United States

Synopsis

Keywords: Flow, Flow, 4D flow MRI; Type 2 diabetes

Motivation: Type 2 diabetes (T2D) is associated with left ventricular (LV) diastolic dysfunction, but the differences in intracardiac function between overweight individuals with and without uncomplicated T2D remain unclear.

Goal(s): This study aimed to identify subclinical intracardiac differences using CMR and 4D flow CMR.

Approach: CMR was used to measure LV global function, strain, and strain rate, and 4D flow CMR was employed for diastolic biomarker analysis. Classification by stroke volume index (SVi) assessed subclinical dysfunction risk and response to exercise.

Results: 4D flow CMR detected diastolic dysfunction in T2D, and improved cardiac function after an exercise intervention in the high SVi group.

Impact: This study demonstrates the feasibility of 4D flow CMR to detect early diastolic dysfunction in overweight individuals with and without type 2 diabetes, providing insights for identifying at-risk individuals to improve cardiac outcomes.

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Abstract

Keywords