Abstract #3043

Macrophage membrane spontaneously encapsulated IL10 biomimetic magnetic nanoparticles for diagnosis and treatment of atherosclerosis

Minjie Cui^1,2, Yueyou Peng¹, Qiufeng Yu³, Rongrong Li², Changlai Jiang², Yongkang Liang³, Xinru Wang², Hanli Jia³, and Yanfeng Meng¹

¹Department of Radiology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China, ²Department of Medical Imaging, Shanxi Medical University, Taiyuan, China, ³Department of Medical Imaging, Changzhi Medical College, Changzhi, China

Synopsis

Keywords: Atherosclerosis, Atherosclerosis

Motivation: Atherosclerosis (AS) is the main cause of most cardiovascular events.

Goal(s): The study was to develop the nanoparticles to improve the curative effect on atherosclerosis.

Approach: We prepared magnetic nanoparticles enveloped IL10 coated with macrophage membrane (MM/IL10-MNPs).For atherosclerotic mouse model, MM/IL10-MNPs were injected and MR images were collected. And we divided the mice into 4 groups. All mice were treated in different ways.

Results: MRI showed T2WI signal intensity was reduced. And the smallest patch area was observed in the MM/IL10-MNPs group.

Impact: In the animal results, MM/IL10-MNPs were able to enhance the active target delivery to atherosclerotic lesions, increase drug concentration in the pathological local and inhibit atherosclerotic development.

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