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Abstract #3048

Determination of Viscosity and Formations of Atherosclerotic Plaque Using Diffusion MRI Analysis

Mayuka Seguchi1, Yuki Kanazawa2, Tosiaki Miyati3, Masafumi Harada2, Mitsuharu Miyoshi4, Tetsuya Wakayama4, Hiroaki Hayashi3, and Akihiro Haga2
1Tokushima University, Tokushima, Japan, 2Tokushima University Graduate School, Tokushima, Japan, 3Kanazawa University, Kanazawa, Japan, 4GE HealthCare, Tokyo, Japan

Synopsis

Keywords: Diffusion Analysis & Visualization, Diffusion Analysis and Visualization

Motivation: To determine physical characteristics of biological tissues non-invasively.

Goal(s): To assess viscosity and formations of atherosclerotic plaque using multi-component analysis of diffusion-weight imaging.

Approach: Bi-exponential diffusion analysis was performed and viscosity of atherosclerotic plaque was converted to the diffusion coefficient using a function derived from an experiment using phantoms.

Results: Twelve plaque tissues were divided into two components, viscous or other materials. The mean diffusion coefficients and were 1.6±3.6 and 4.7±3.7 mm2/s.

Impact: Non-invasively obtaining detailed information on the viscosity and formations of atherosclerotic plaque.

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Keywords