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Abstract #3058

MEMRI as a tool for studying biomagnetism of the electromagnetic perceptive gene (EPG) protein.

Brianna Ricker1, Nir Dayan1, and Assaf A. Gilad1
1Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, United States

Synopsis

Keywords: Molecular Imaging, Molecular Imaging, Manganese-enhanced MRI (MEMRI)

Motivation: Development of magnetogenetic technologies for neuromodulation.

Goal(s): Observe changes in intracellular Mn2+ by way of the electromagnetic perceptive gene (EPG) protein as Ca2+analog in in vitro models to warrant further investigation in vivo.

Approach: Lysate of HEK293FT cells expressing EPG exposed to MnCl2 and magnetic stimulus were measured using MRI and compared to T1 values from several controls.

Results: Cells expressing EPG and exposed to magnetic stimulus plus MnCl2 have significantly decreased T1 values compared to lysate from cells exposed to MnCl2 without EPG.

Impact: These results strongly indicate the potential of manganese-enhanced MRI (MEMRI) to significantly accelerate the development of magnetogenetics as a transformative tool for neuromodulation. MEMRI can facilitate magnetogenetics toward clinical translation for neural manipulation, thereby enhancing options for treating neurological disorders.

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