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Abstract #3060

Cascade-activated CEST nanoplatforms for guided tumor pyroptosis

Jiali Deng1, Xiance Zhao2, and Zhongling Wang3
1Radiology department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Philips Healthcare, Shanghai, China, 3Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

Synopsis

Keywords: Molecular Imaging, Visualization, CEST activation imaging; cell pyroptosis; nanoprobes; breast cancer

Motivation: How to noninvasively visualize the tumor pyroptosis process using clinical MR techniques is important for image-guided precision tumor therapy.

Goal(s): The goal of this study was to construct a highly sensitive CEST MR molecular imaging nanoplatform for label-free visualization of tumor pyroptosis.

Approach: In this study, we introduced a microenvironmental response cascade-activated CEST nanoplatform to dynamically visualize the expression of markers associated with pyroptosis.

Results: We found that the nanoplatform allows for a versatile non-invasive imaging of the pyroptosis process in tumors, including drug release monitoring, quantification of pyroptosis markers, and assessment of the efficacy of pyroptosis immunotherapies.

Impact: We developed a smart CEST nanoplatform for non-invasive visualization of the pyroptosis process, providing a new strategy for precision tumor therapy. The nanoprobe was shown to be useful for 3T MR and is expected to be used in the clinic.

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