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Abstract #3065

Nanoparticles Amplify Tumor Targeting via In Vivo Coagulation Cascade for 19F MRI of Ultrasmall Pulmonary Metastases

Ruifang Wang1, Daiqin Chen1, Shizhen Chen1, and Xin Zhou1
1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China

Synopsis

Keywords: Molecular Imaging, Molecular Imaging

Motivation: Clinical studies emphasize that early detection of metastases is crucial to prevent disease progression and improve the chances of a cure.

Goal(s): Diagnose early-stage metastatic lung cancer using 19F MRI.

Approach: l We developed a dual-component nanoplatform for detecting pulmonary metastases with enhanced targeting in 19F MRI. Using DMXAA, a vascular-disrupting agent, we induced precise coagulation at metastatic lung lesions. This coagulation recruits the 19F MRI probe (CFlip NPs), specifically targeting polymerized fibrin.

Results: Activation of the coagulation cascade successfully amplified targeting in both subcutaneous and lung tumor models, demonstrating strong potential for early metastatic detection in clinical settings.

Impact: This platform provides a significant step forward in precise tumor imaging, opening avenues for improved diagnostic accuracy and timely intervention in metastatic lung cancer.

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