Keywords: Molecular Imaging, Molecular Imaging
Motivation: Clinical studies emphasize that early detection of metastases is crucial to prevent disease progression and improve the chances of a cure.
Goal(s): Diagnose early-stage metastatic lung cancer using 19F MRI.
Approach: l We developed a dual-component nanoplatform for detecting pulmonary metastases with enhanced targeting in 19F MRI. Using DMXAA, a vascular-disrupting agent, we induced precise coagulation at metastatic lung lesions. This coagulation recruits the 19F MRI probe (CFlip NPs), specifically targeting polymerized fibrin.
Results: Activation of the coagulation cascade successfully amplified targeting in both subcutaneous and lung tumor models, demonstrating strong potential for early metastatic detection in clinical settings.
Impact: This platform provides a significant step forward in precise tumor imaging, opening avenues for improved diagnostic accuracy and timely intervention in metastatic lung cancer.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords