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Abstract #3068

Dual mms6/magA gene expression, improves contrast in cancer cells for MR imaging

Vala Masjedizadeh1, Jason Langley 1, William Darch1, Joshua Morgan1, and Xiaoping Hu1
1Bioengineering, University of California, Riverside, Riverside, CA, United States

Synopsis

Keywords: Molecular Imaging, Molecular Imaging, Reporter Gene, Cancer

Motivation: MRI reporter genes can be used for cancer diagnosis; however, MRI reporter genes are often cytotoxic.

Goal(s): Our goal was to use a combination of magnetotactic bacterial genes (mms6 and magA) to design a reporter gene for enhanced MRI contrast.

Approach: Wild type and transgenic cancer cell lines containing the designed reporter gene were imaged and R2 was mapped for each cell type.

Results: Cells containing the dual gene demonstrated higher R2 values and iron uptake.

Impact: Our demonstration that the dual expression genes provide enhanced contrast with minimal toxicity to the cells, indicates dual expression of mms6 and magA is a suitable MRI reporter gene that can be incorporated for cancer diagnostics.

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