Keywords: Molecular Imaging, Molecular Imaging, Reporter Gene, Cancer
Motivation: MRI reporter genes can be used for cancer diagnosis; however, MRI reporter genes are often cytotoxic.
Goal(s): Our goal was to use a combination of magnetotactic bacterial genes (mms6 and magA) to design a reporter gene for enhanced MRI contrast.
Approach: Wild type and transgenic cancer cell lines containing the designed reporter gene were imaged and R2 was mapped for each cell type.
Results: Cells containing the dual gene demonstrated higher R2 values and iron uptake.
Impact: Our demonstration that the dual expression genes provide enhanced contrast with minimal toxicity to the cells, indicates dual expression of mms6 and magA is a suitable MRI reporter gene that can be incorporated for cancer diagnostics.
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