Keywords: Deuterium, Deuterium
Motivation: We wished to determine the feasibility of using deuterium metabolic imaging (DMI) for assessing glucose metabolism in human leg muscles in normal volunteers to establish a baseline for future work in muscular diseases.
Goal(s): The goal of this study is to determine whether DMI could be used in muscles for establishing baseline measurements.
Approach: We used 6,6-2H-glucose and 2H-MRSI at 7T to assess glucose metabolism in eight normal participants between 10 minutes and two hours.
Results: Small changes were observed in muscle ²H-glucose signal intensity between the initial and final scans. Muscle ²H-glucose or ²H-Glx levels varied among participants, suggesting differential metabolism.
Impact: Deuterated metabolic imaging (DMI) has the potential to revolutionize the assessment of muscle glucose metabolism, enabling clinicians to better diagnose and manage musculoskeletal disorders. This research establishes baseline methods before applying DMI in musculoskeletal disorders.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords