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Abstract #3082

Muscle Glucose Uptake using Deuterium Metablic Imaging (DMI) at 7T

Joshua Daniel Kaggie1, Bianca Buchignani2,3, Pierfrancesco Ambrosi4, Paolo Cechi3,5, Giacomo Aringhieri3, Christoffer Laustsen6, Rolf Schulte7, and Michela Tosetti4
1Radiology, University of Cambridge, Cambridge, United Kingdom, 2Neuroscience, IRCCS Stella Maris, Pisa, Italy, 3Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, 4Laboratory of Medical Physics and Magnetic Resonance, IRCCS Stella Maris, Pisa, Italy, 5Imago 7 Research Foundation, Pisa, Italy, 6Clinical Medicine, the MR Research Centre, Aarhus University, Aarhus, Denmark, 7GE Healthcare, Munich, Germany

Synopsis

Keywords: Deuterium, Deuterium

Motivation: We wished to determine the feasibility of using deuterium metabolic imaging (DMI) for assessing glucose metabolism in human leg muscles in normal volunteers to establish a baseline for future work in muscular diseases.

Goal(s): The goal of this study is to determine whether DMI could be used in muscles for establishing baseline measurements.

Approach: We used 6,6-2H-glucose and 2H-MRSI at 7T to assess glucose metabolism in eight normal participants between 10 minutes and two hours.

Results: Small changes were observed in muscle ²H-glucose signal intensity between the initial and final scans. Muscle ²H-glucose or ²H-Glx levels varied among participants, suggesting differential metabolism.

Impact: Deuterated metabolic imaging (DMI) has the potential to revolutionize the assessment of muscle glucose metabolism, enabling clinicians to better diagnose and manage musculoskeletal disorders. This research establishes baseline methods before applying DMI in musculoskeletal disorders.

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