Abstract #3085

Measuring the rapid uptake of 2H in the brain following ingestion of heavy water

Daniel Cocking^1,2, Robin Damion^1,3,4, Matthew Brook^4,5,6, Dorothee Auer^1,3,4, and Richard Bowtell^1,2

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ³Radiological Sciences, Mental Health and Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁴NIHR Nottingham Biomedical Research Centre/Nottingham Clinical Research Facilities, Queen's Medical Centre, Nottingham, United Kingdom, ⁵MRC-Versus Arthritis Centre for Muscoskeletal Ageing Research, University of Nottingham, Nottingham, United Kingdom, ⁶School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Deuterium, Deuterium

Motivation: Analysis of ²H concentration in tissue samples following heavy water (D₂O) ingestion is useful for assessing body composition, lipid synthesis and protein turnover.

Goal(s): Evaluate the feasibility of using ²H MRI to monitor the rapid uptake of ²H in the brain immediately following ingestion of heavy water.

Approach: 3D EPI time series were acquired on three subjects after ingestion of ~100 ml of D₂O. Two subjects already had elevated ²H baselines whilst the third started at natural abundance.

Results: Similar time-courses of the ²H signal change in cerebrospinal fluid, grey matter and white matter were reliably measured in all subjects.

Impact: This study demonstrates the feasibility of using ²H MRI to non-invasively monitor deuterium rapid changes in the distribution of deuterium label in brain tissues. This can support research on lipid synthesis, protein turnover, and other physiological processes with minimal invasiveness.

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