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Abstract #3093

Assessing the healing of juvenile osteochondritis dissecans lesions quantitatively with a 7T 3D MRI sequence and T2* mapping

Saumith Bachigari1, Rohan Raikar1, Michael Newcome1, Abdul Wahed Kajabi1, Brent Burg1, Marc Tompkins2, Jutta Ellermann1, and Eisa Hedayati1
1Radiology, University of Minnesota, Minneapolis, MN, United States, 2Orthopedic Surgery, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Joint, Joints, Segmentation, Novel analysis

Motivation: Juvenile osteochondritis dissecans (JOCD) heals naturally in some patients, but requires surgery with others. Currently, no protocol exists to determine early if a child needs early surgical intervention, which leads to a waiting period where patients suffer prolonged pain.

Goal(s): Differentiate healing JOCD lesions from non-healers without surgical intervention using T2* mapping analysis.

Approach: Segment JOCD lesions on 3D 7T T2* MRI scans longitudinally and analyze T2* values of the region of interest to determine significant changes for healers.

Results: Healing lesions showed a decrease in T2* over time. Non-healing lesions showed an increase in T2* values.

Impact: We found that JOCD lesions can be differentiated as healers or non-healers, as early as 3 months, by utilizing T2* mapping with 7T MRI. Previously, this was not possible at the 1.5T and 3T standards widely used by clinicians.

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Keywords