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Abstract #3104

Evaluation of a 5-minute, clinically feasible T2 mapping sequence to detect ischemic injury to the developing femoral head: a piglet model study

Casey P. Johnson1,2, Suhail P. Parvaze1,2, Nicole R. Nelson1, Scott Novom1, Ashton A. Amann1, Erick O. Buko1,2, Steen Moeller2, Alexandra R. Armstrong1, and Ferenc Toth1
1Department of Veterinary Clinical Sciences, University of Minnesota, Saint Paul, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Bone/Skeletal, MSK

Motivation: T2 mapping may be useful to assess the severity of ischemic injury to the femoral head in children with Legg-Calvé-Perthes disease.

Goal(s): To determine whether a 5-minute, clinically available T2 mapping sequence suitable for imaging children can detect ischemic injury in a piglet model.

Approach: N=24 piglets were imaged in vivo at 3T MRI before and 0 to 14 days after onset of femoral head ischemia. T2 maps acquired using 5-minute 2D MSME and 12-minute 3D SPACE sequences were compared using 3D region of interest analyses.

Results: The 5-minute sequence reliably detected increased T2 values following ischemic injury to the femoral head.

Impact: Ischemic injury to the femoral head can be detected using a 5-minute, clinically available T2 mapping sequence that is suitable for imaging young children. This technique may facilitate clinical translation of T2 mapping for detection and monitoring of Legg-Calvé-Perthes disease.

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Keywords