Keywords: Bone/Skeletal, Animals
Motivation: Hydrogen sulfide (H2S) donors or agonists may offer a new approach to treat diabetes-related bone micro-environment abnormalities.
Goal(s): To find a non-invasive and effective method to assess the biological effects of exogenous H2S intervention.
Approach: Quantitative MRI was used to evaluate the oxidative stress level in bone marrow endothelial cells and bone micro-structural changes in a diabetic rabbit model with critical limb ischemia following exogenous H2S intervention.
Results: Exogenous H2S reduces the bone marrow microvascular permeability and bone marrow fat content by reducing the oxidative stress level of bone marrow vascular endothelial cells, improved bone microstructure of diabetic rabbits with CLI.
Impact: This study provides quantitative imaging evidence for the protective mechanism of H₂S in diabetic critical limb ischemia complications.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords