Keywords: Aging, Neurodegeneration, Frontotemporal Dementia, QSM, Chi Separation, Alzheimer's, Paramagnetic, Diamagnetic
Motivation: Syndrome-specific patterns of iron-rich cortical gliosis have been demonstrated postmortem in Frontotemporal Lobal Degeneration (FTLD) but have not been reliably detected in vivo.
Goal(s): Evaluate whether Chi-separation and/or Quantitative Susceptibility Mapping (QSM) can reliably detect regional changes in cortical paramagnetism in behavioral variant frontotemporal dementia (bvFTD) patients.
Approach: Patients with bvFTD, Alzheimer’s disease, and one age-matched control were imaged at 3T using a multi-gradient echo sequence. Both QSM and Chi-separation maps were analyzed within DKT cortical regions associated with expected pathology.
Results: Chi-separation paramagnetic maps showed statistically significant increases in anterior cingulate, a region of expected pathology.
Impact: We show that chi-separations maps can be used to detect syndrome-specific paramagnetic cortical changes, demonstrating its ability to quantify the distribution of iron-rich gliosis in vivo in FTLD, which has previously only been reliably visualized postmortem.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords