Keywords: White Matter, Transplantation, COVID-19
Motivation: Fatigue affects over half of kidney transplant recipients (KTRs), investigating white matter (WM) microstructure in KTRs could guide targeted interventions.
Goal(s): This study aims to identify WM microstructural characteristics in KTRs, their contribution to fatigue, and relevant renal function indicators, while assessing their predictive role in post-COVID-19 fatigue development.
Approach: We used DKI-based tract-based spatial statistics to compare WM microstructure between KTRs and HCs, examining its relationship with renal function and fatigue.
Results: KTRs showed reduced microstructural complexity in the right cingulum hippocampus tract compared to HCs, a predictor of both current and post-COVID-19 fatigue, with urea levels significantly impacting this association.
Impact: This study suggests that WM complexity may be a biomarker for fatigue progression in KTRs, potentially linking renal function to neuropsychiatric symptoms. These findings offer insights into mechanisms underlying fatigue in KTRs and point to possible therapeutic targets.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords