Abstract #3147

Anisotropy and Field Strength Dependence of Relaxation Rates in Single and Crossing Fiber White Matter

Melanie Bauer¹, Christian Kremser¹, Elke Gizewski^1,2, Claudia Lenz^3,4, and Christoph Birkl^1,2

¹Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria, ²Neuroimaging Research Core Facility, Medical University of Innsbruck, Innsbruck, Austria, ³Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ⁴Institute of Forensic Medicine, Health Department Basel-Stadt, University of Basel, Basel, Switzerland

Synopsis

Keywords: White Matter, Microstructure, Anisotropy

Motivation: The effect of field strength on the orientation dependence of relaxation rates in voxels containing distinct fiber populations remains unexplored.

Goal(s): The aim was to investigate fiber orientation dependent relaxation rates in single and crossing fiber voxels across different field strengths.

Approach: Four volunteers were scanned at 1.5 and 3 T to asses the anisotropy of R₂, R₂^* and R₂’ in regions corresponding to single and two crossing fibers.

Results: R₂, R₂^* and R₂’ and their anisotropies are influenced by fiber orientation and field strength, with distinct differences observed between single and two crossing fibers.

Impact: This study deepens our understanding of fiber orientation and field strength effects on relaxation rates in brain white matter, providing essential insights into underlying mechanisms leading to relaxation anisotropy. This will enable more detailed analyses of complex fiber structures.

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