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Abstract #3150

Quantitative Analysis of White Matter Hyperintensities and Their Association with Cognitive Impairment in End-Stage Renal Disease Patients

Qiange Zhu1, Junya Mu2, Shaohui Ma2, Ruitao Zhang1, Huijie Yuan2, Zhengshu Han1, Ming Zhang2, and Yuchen Liu3
1Xi'an Jiaotong University, Xi'An, China, 2The First Affiliated Hospital of Xi 'an Jiaotong University, Xi'An, China, 3GE HealthCare MR Research, Beijing, China

Synopsis

Keywords: White Matter, Neuro

Motivation: Cognitive impairment in end-stage renal disease (ESRD) often accompanies white matter hyperintensities, yet their relationship remains poorly understood.

Goal(s): To quantify WMH in ESRD patients and examine its association with cognitive function, particularly in the juxtaventricular (JVWMH) region.

Approach: A cross-sectional study with MRI imaging and MoCA assessment was conducted on 48 ESRD patients and 48 matched controls, asscessing WMH volumes and their relationship to cognitive scores.

Results: ESRD patients exhibited higher WMH volumes, especially in the JVWMH region, correlating with decreased MoCA scores.

Impact: This study suggested that JVWMH volume may serve as a potential marker for cognitive decline in ESRD patients.These findings may offer valuable insights for developing targeted interventions and encourage further research into the neurovascular mechanisms underlying cognitive impairment in renal disease.

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