Abstract #3163

Association of Iron Level in the Nucleus Accumbens with Cognitive Impairment in Preeclampsia

Boyao Chen¹, Linfeng Yang², Tao Chen³, Meng Li⁴, Lingfei Guo⁵, Na Wang⁵, Xinyue Zhang⁵, Yuanyuan Wang⁶, Zhenyu Cheng⁷, Pengcheng Liang⁵, Yiwen Chen⁵, Xinxin Huo⁵, and Fushuai Zhang⁷

¹Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, Jinan, China, China, ²Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China, Jinan, China, China, ³Department of Clinical laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan 250001, Shandong Province, China, Jinan, China, China, ⁴Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany, Jena, Germany, ⁵shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Jinan, China, China, ⁶School of Medical Imaging，Binzhou medical university,Yantai,Shandong,China, Yan, China, China, ⁷School of Medical Imaging，Binzhou medical university,Yantai,Shandong,China, Yantai, China

Synopsis

Keywords: Other Neurodegeneration, Brain, Quantitative susceptibility mapping, Striatum, Preeclampsia, Cognitive impairment

Motivation: This study aims to investigate alterations in susceptibility values obtained from quantitative susceptibility mapping (QSM) of the striatum in patients with preeclampsia, focusing on the correlation between these alterations and cognitive impairment.

Goal(s): The objective is to clarify the relationship between susceptibility values and cognitive impairment in preeclampsia patients, as well as to explore the associated contributing factors.

Approach: Prospective cohort study

Results: Our study revealed higher susceptibility values of nucleus accumbens(NAc) in preeclampsia patients. A correlation between the susceptibility values and a decline in executive function was observed.

Impact: This study introduces a novel indicator that utilizes QSM techniques for early prediction of preeclampsia and associated cognitive impairment, potentially improving diagnostic accuracy and intervention strategies.

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