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Abstract #3165

Association Between Type 2 Diabetes Mellitus and Cognitive Impairment Mediated by Imaging Markers of the Glymphatic System

Peichun Pan1, Jie Gao1, Kai Ai2, Xiaoyan Lei1, and Xiaoling Zhang1
1Shaanxi Provincial People's Hospital, Xi'an, China, 2Department of Clinical and Technical Support, Xi‘an, China

Synopsis

Keywords: Other Neurodegeneration, Diabetes

Motivation: To investigate whether glymphatic markers and hippocampal atrophy mediate the relationship between type 2 diabetes mellitus (T2DM) and cognitive function.

Goal(s): To export the correlations between glymphatic markers and cognitive function in T2DM patients.

Approach: Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, total perivascular spaces (PVS) volume and hippocampal volume were obtained. The relationship between cognitive function and DTI-ALPS index, total PVS volume, hippocampal volume of T2DM patients was analyzed.

Results: The T2DM patients had worse general cognitive function, larger total PVS volume, and smaller DTI-ALPS index. The glymphatic markers mediated the relationship between T2DM and cognitive function.

Impact: The glymphatic markers is a promising imaging marker for cognitive impairment and may provide clinicians with important information for planning treatment strategies and assessing prognosis in T2DM patients.

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