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Abstract #3170

Evaluation of Physiological Characteristics of in vivo AGN Probe Using Multimodal Imaging

Norikazu Koyasu1, Hiroyuki Yatabe2, Yoichi Takakusagi3, Yutaro Saito2, Shinsuke Sando2, Murali C. Krishna1, and Kazutoshi Yamamoto1
1National Institutes of Health, Bethesda, MD, United States, 2The University of Tokyo, Tokyo, Japan, 3National Institutes for Quantum Science and Technology, Chiba, Japan

Synopsis

Keywords: Biomarkers, biomarkers

Motivation: Monitoring the enzymatic activity of APN in tumors non-invasively can improve cancer diagnostics and therapy. A hyperpolarized AGN probe is a key biomarker for APN

Goal(s): This study aimed to validate the physiological characteristics of AGN probes in vivo

Approach: We used hyperpolarized 13C MRS and EPSI to measure APN activity in tumors with varying APN expression. DCE-MRI, DWI, and EPR imaging to evaluate several tumor physiological parameters

Results: The AGN probe distinguished high and low APN-expressing tumors, even in low permeability and hypoxic regions, showing promise for personalized cancer treatment

Impact: The hyperpolarized AGN probe provides a novel, non-invasive method for real-time monitoring of APN activity in tumors, even in hypoxic and low-perfusion regions, thus providing therapeutic strategies and personalized cancer treatment

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Keywords