Abstract #3172

A Multi-Parameter Mapping (MPM) protocol optimized for the mouse brain

Jérémie P. Fouquet¹, Mila Urosevic^1,2,3, Yohan Yee^2,4, Yuhan Liu², Kawthar A. Moshref^2,5, Daniel Gallino¹, Gabriel A. Devenyi^2,4, and M. Mallar Chakravarty^1,2,3,4

¹Cerebral Imaging Centre, Douglas Research Centre, Montreal, QC, Canada, ²Computational Brain Anatomy Laboratory, Cerebral Imaging Centre, Douglas Research Centre, McGill University, Montreal, QC, Canada, ³Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada, ⁴Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁵Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada

Synopsis

Keywords: Small Animals, Quantitative Imaging

Motivation: Although multi-parameter mapping (MPM) protocols are widespread and add value in human studies, no equivalent exists for the mouse brain.

Goal(s): To optimize and characterize an MPM protocol for the mouse brain.

Approach: We optimized the parameters of an MPM sequence theoretically and empirically, then characterized it with a tailored pipeline and a test-retest design.

Results: A mouse-brain optimized, high-contrast MPM protocol with accompanying coefficient of variations for future power analysis.

Impact: An MPM protocol optimized for the mouse brain is now available and characterized, enabling the study of the cerebral microstructure in preclinical models with high translational potential.

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