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Abstract #3179

Simultaneous MRI oximetry and electrical recording in the brain using ECoG electrodes infused with pO2 reporter molecules

Charmayne Dawn Seaton1, Livia De Mesquita Teixeira1, Yuka Sugamura1, Samrat Amin2, Jitendran Muthuswamy1, and Vikram Kodibagkar1
1School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States, 2Arizona State University, Tempe, AZ, United States

Synopsis

Keywords: Biology, Models, Methods, Oxygenation

Motivation: Current technologies limit the capabilities of measuring pO2 levels in multiple locations while recording neural activity using surface electrodes.

Goal(s): To demonstrate that we can measure brain cortical pO2 and response to oxygen breathing simultaneously with electrical recordings.

Approach: We utilized MRI to measure oxygenation levels using proton imaging of siloxanes to map tissue oxygenation levels (PISTOL). Tetradecamethylhexasiloxane (L6) was used as a pO2 reporter molecule and infused into the polydimethylsiloxane (PDMS) coating of ECoG electrodes implanted into rat brains (n=3).

Results: We recorded an increase in pO2 between air and oxygen breathing states of three rats while simultaneously examining the neural activity.

Impact: Researchers aiming to measure neuronal activity would benefit from the additional quantitative pO2 measurements during rest, brain stimulations, and disease models such as stroke.

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Keywords