Meeting Banner
Abstract #3194

Clinical Feasibility and Tolerance of Oxygen-Enhanced MRI for Assessing Tumor Hypoxia in Nasopharyngeal Carcinoma

Fan Chen1, Jing Li1, Shao xin Xiang2, and Wei Chen1
1Department of Radiology, Southwest Hospital, Army Medical University, Chong Qing, China, 2MR Collaboration, United Imaging Research Institute of Intelligent Imaging, Beijing, China, Bei Jing, China

Synopsis

Keywords: Data Acquisition, Acquisition Methods

Motivation: Oxygen-enhanced magnetic resonance imaging (OE-MRI) is an attractive technique that monitor tumour oxygenation.

Goal(s): To investigate if dynamic T1-mapping with OE-MRI could be performed to detect hypoxia in NPC. And, to assess differences of OE-MRI-derived parameters between the NPC and the opposite side lateral pterygoid muscle (termed YWJ).

Approach: Thirteen NPC patients were scanned the OE-MRI. Baseline tissue longitudinal relaxation time (T1) and 1/T1 (termed R1) was measured alongside the change in R1 (termed ΔR1) between air and oxygen gas breathing phases.

Results: The ΔR1 of oxygen gas breathing phases in both NPC and YWJ were significantly higher than air breathing.

Impact: Dynamic T1-mapping with OE-MRI to indicate hypoxia of NPC and the derived parameter ΔR1 may be a repeatable hypoxia biomarker. OE-MRI is promising to guide clinical work of biology guided adaptive radiotherapy.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords