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Abstract #3198

Magnetic Resonance Histopathology (MRH): a direct, noninvasive, and low-cost diagnostic for quantitative microarchitecture imaging.

Timothy W James1, Arnold Benjamin2, Samantha J. Ma3, Ruslan Garipov2, Gérard Crelier4, Quin Lu5, Fei Han3, Dallas C Turley6, Kristin W James1, Naomi S. Sta Maria7, Kyle J Williams8, Ian D. Parker8, and Russell E. Jacobs7
1BioProtonics,Inc., Santa Barbara, CA, United States, 2MR Solutions, Guildford, United Kingdom, 3Siemens Medical Solutions USA, Malvern, PA, United States, 4GyroTools, Zürich, Switzerland, 5GE Healthcare, San Francisco, CA, United States, 6Philips Healthcare, Cambridge, MA, United States, 7University of Southern California, Los Angeles, CA, United States, 8BioProtonics, Inc., Santa Barbara, CA, United States

Synopsis

Keywords: New Trajectories & Spatial Encoding Methods, Tissue Characterization, Quantitative imaging

Motivation: To provide a non-invasive, rapid, low-cost diagnostic imaging method to quantitatively characterize microscopic tissue textures currently unresolvable by diagnostic imaging.

Goal(s): Quantitative assessment of microscopic textures in the 10 to 1500 micrometer range with voxel dimensions similar to DWI. Either individual or multiple voxels providing multi-slice images in clinically relevant acquisition times.

Approach: Excite a voxel and interrogate with a k-encode matching the spatial frequency being probed. Single voxel or multiple using a "read gradient" to separate multiple voxels.

Results: MRH has demonstrated 39 µm resolution preclinically and 100 µm clinically in phantoms probing 6000 VOI in 20 seconds. Prostate scans confirm functionality.

Impact: MRH provides a currently inaccessible quantitative measure of sentinel tissue microscopic characteristics enabling more informed diagnosis, reducing the need for excisional observation.

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Keywords