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Abstract #3203

Quantitative in-vivo analysis of biomechanical properties reveals tissue stiffness changes during contraction of the thigh muscles.

David G.J. Heesterbeek1, Max H.C. van Riel1, Ray Sheombarsing1, Tristan van Leeuwen2, Martijn Froeling3, Cornelis A.T. van den Berg1, and Alessandro Sbrizzi1
1Computational Imaging Group for MR diagnostics & therapy, University Medical Center Utrecht, Utrecht, Netherlands, 2Centrum Wiskunde & Informatica, Amsterdam, Netherlands, 3High Field Group, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Signal Representations, Tissue Characterization, Muscle, quantitative reconstruction, elastography

Motivation: Quantitative in-vivo analysis of muscle stiffness provides insight in the functioning of the musculoskeletal system, but no robust reconstruction algorithm is available that uses displacement fields on a physiological time-scale.

Goal(s): Development of a robust reconstruction approach for quantitative biomechanical properties without using boundary information.

Approach: An inflatable pressure cuff is used to induce deformations in thigh muscles during an MRI scan. Time-resolved displacement fields are recontructed and used to distill quantitative stiffness information for relaxed and contracted muscles.

Results: Nummerical tests and an in-vivo repeatability study corroborate the validity of the proposed approach. An increase in stiffness is observed during muscle contraction.

Impact: Access to in-vivo stiffness parameters could give insight in muscle functionality. We developed an algorithm that is able to recontruct quantitative biomechanical properties from information acquired during a simple dynamic loading experiment without using boundary information.

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Keywords