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Abstract #3206

Rapid T1 Relaxation Time Quantification with Enhanced Accuracy Using Simultaneous Acquisition of Phase-Encoding in Inversion-Recovery EPI

Seong Dae Yun1 and N. Jon Shah1,2,3,4
1Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Juelich, Juelich, Germany, 2Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Juelich, Juelich, Germany, 3JARA - BRAIN - Translational Medicine, Aachen, Germany, 4Department of Neurology, RWTH Aachen University, Aachen, Germany

Synopsis

Keywords: Pulse Sequence Design, Pulse Sequence Design, Accurate T1 mapping, Geometric Distortion Correction, EPI, Inversion Recovery, T1 relaxation time, and Quantitative Imaging

Motivation: The inversion-recovery method for T1 mapping typically requires a relatively long acquisition time which can be significantly shortened using EPI techniques. However, substantial geometric distortions in EPI often hinder accurate T1 quantification.

Goal(s): We propose a novel IR-EPI scheme that simultaneously acquires EPI data with the reversed phase-encoding direction in a single IR measurement.

Approach: Geometric distortions of IR-EPI data were corrected using the blip-up/blip-down approach. Its performance was evaluated in direct comparison to that of original IR-EPI.

Results: The proposed scheme enables effective distortion correction for IR-EPI data, enhancing T1 mapping accuracy while providing rapid, whole-cerebrum acquisition at 7T.

Impact: The proposed IR-EPI scheme enables effective geometric distortion correction in IR-EPI data, with only a negligible increase in scan time. Consequently, the greater structural similarity to co-registered MP2RAGE significantly enhances T1 mapping accuracy, while providing rapid, whole-cerebrum acquisition at 7T.

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Keywords