Keywords: Software Tools, Spectroscopy
Motivation: MRS enables non-invasive quantification of brain metabolites, but its reliability is crucial for accurate interpretation.
Goal(s): This study assessed the test-retest of 31P-MRS and 1H-MEGA-PRESS in measuring phosphorus-31 metabolites, GABA, GSH using a 3T system.
Approach: 32 participants underwent two scanning sessions within three days. GABA+, Glx, GSH, and ten 31P metabolites were analyzed based on CV and Bland-Altman plots.
Results: The CV of GPE, GPC, -ATP, -ATP, pH and Mg2+ was below 10%, PE, PC, -ATP, Pi, GPTC was over 10%. The CV of GABA+/Cr, GABA+/water, Glx/Cr, Glx/water were below 4%; GSH/Cr, GSH/water were 11.904% and 16.525%.
Impact: This study reveals the range of reliability of MEGA-edited GABA+, Glx and 31P-MRS techniques in application.
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