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Abstract #3213

Test-Retest Precision of Brain Metabolites in Healthy Participants using 31P-MRS and 1H MEGA-PRESS at 3T Multi-nuclear MRI System

Shuang Hu1, Wenzhen Zhu1, and Xiaoxiao Zhang2
1Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan,China, China, 2Clinical Technical Solutions, Philips Healthcare, Beijing, China, Wuhan,China, China

Synopsis

Keywords: Software Tools, Spectroscopy

Motivation: MRS enables non-invasive quantification of brain metabolites, but its reliability is crucial for accurate interpretation.

Goal(s): This study assessed the test-retest of 31P-MRS and 1H-MEGA-PRESS in measuring phosphorus-31 metabolites, GABA, GSH using a 3T system.

Approach: 32 participants underwent two scanning sessions within three days. GABA+, Glx, GSH, and ten 31P metabolites were analyzed based on CV and Bland-Altman plots.

Results: The CV of GPE, GPC, -ATP, -ATP, pH and Mg2+ was below 10%, PE, PC, -ATP, Pi, GPTC was over 10%. The CV of GABA+/Cr, GABA+/water, Glx/Cr, Glx/water were below 4%; GSH/Cr, GSH/water were 11.904% and 16.525%.

Impact: This study reveals the range of reliability of MEGA-edited GABA+, Glx and 31P-MRS techniques in application.

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