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Abstract #3249

Arterial input function derived using the Xiphoid process as a reference tissue for breast DCE-MRI

Xiaobing Fan1, Zhen Ren1, Hiroyuki Abe1, Olufunmilayo I. Olopade2, and Gregory S. Karczmar1
1Radiology, The University of Chicago, Chicago, IL, United States, 2Medicine, The University of Chicago, Chicago, IL, United States

Synopsis

Keywords: Data Processing, Analysis/Processing

Motivation: Solve the problem of accurately measuring the arterial-input-function (AIF) for breast DCE-MRI at 3T.

Goal(s): To derive AIF from Xiphoid-process and compare with AIFs measured from the aorta with low and high dose (15% and 85% of standard-dose) DCE-MRI.

Approach: DCE-MRI were acquired at 3T. Ktrans and ve for Xiphoid-process were measured with low-dose AIF using standard Tofts model, then used to derive AIF for high dose, and compared with high dose AIFs.

Results: AIF derived using the Xiphoid-process has significantly higher peak than that measured from the aorta with a high dose, and can be used for quantitative analysis of breast DCE-MRI.

Impact: The AIF derived using the Xiphoid-process as a reference tissue has significantly higher peak than that measured at descending aorta for regular-dose breast DCE-MRI, and can be used to quantitatively analyze breast DCE-MRI for diagnosis of breast cancer.

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Keywords