Keywords: fMRI Analysis, MR Value, 1.MR; 2. Morphological Features; 3. DCE Functional Parameters; 4. Colorectal Liver Metastasis；5. Chemotherapy Response Prediction.
Motivation: Given the potential toxicities associated with chemotherapy in patients with CRLM (colorectal liver metastasis), identifying imaging features that can effectively predict treatment response is crucial.
Goal(s): To evaluate the spatiotemporal tumor heterogeneity in CRLM using DCE-MRI and compare the differences between morphometric features and functional parameters in predicting chemotherapy effectiveness.
Approach: A prospective study was conducted on CRLM patients receiving standard first-line chemotherapy, analyzing 18 morphometric features and 90 functional parameters from multiple tumor spatial subregions on DCE-MRI at baseline and early post-treatment.
Results: The morphometric model outperformed the functional model in predicting chemotherapy effectiveness (AUC, 0.94 vs. 0.66, P < .001).
Impact: This study reveals the potential role of MRI morphometric features in predicting chemotherapy response in CRLM, providing a practical and effective tool for clinical decision-making.
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