Abstract #3256

RaPPiD: A Region-Specific MRI Metric for Assessing Glymphatic Function and Its Relation to Sleep Quality and Cardiovascular Health

Yaqiong Chai¹, Harmony Selena Cen², Andrew Shinho Kim³, Gilsoon Park², Emily Goun Lee⁴, Kirsten Lynch⁵, Kyung Wook Kang⁶, and Hosung Kim²

¹University of Southern California, South Pasadena, CA, United States, ²Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ³Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States, ⁴Undergraduate Neuroscience Interdepartmental Program, University of California - Los Angeles, Los Angeles, CA, United States, ⁵University of Southern California, Los Angeles, CA, United States, ⁶Chonnam National University Medical School, Chonnam National University, Gwangju, Korea, Republic of

Synopsis

Keywords: Data Processing, Diffusion Analysis and Visualization, Glymphatic function

Motivation: The glymphatic system plays a vital role in clearing waste from the brain, yet current imaging techniques lack regional specificity, overlooking crucial cortical areas and subcortical white matter (sWM).

Goal(s): Develop a metric, RaPPiD to measure glymphatic function within defined brain regions, linking it to sleep quality.

Approach: Using T2 MRI and multi-shell diffusion-weighted imaging, we isolated water diffusivity in periarterial spaces , calculating RaPPiD as a ratio of perpendicular to parallel PAS diffusivity in nine functional sWM ROIs.

Results: RaPPiD successfully identified region-specific associations, with lower RaPPiD in FPN and limbic regions correlating with higher PSQI scores.

Impact: This study's development of RaPPiD enables precise, region-specific assessment of glymphatic function, advancing understanding of brain waste clearance. Clinicians may use RaPPiD to identify glymphatic impairments linked to sleep and cardiovascular health, guiding potential interventions and research in neurodegenerative disease.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.