Keywords: Susceptibility/QSM, Susceptibility
Motivation: The static dephasing regime, which neglects diffusion effects, is typically assumed for modeling magnetic susceptibility effects within a voxel. Given the complexity of brain microstructure, this assumption warrants further investigation.
Goal(s): This work aims to assess the validity of the static dephasing regime under varying diffusion conditions within two brain cell types.
Approach: Monte Carlo simulations were performed to model spin diffusion around myelinated axons and astrocytes under different diffusion conditions.
Results: Spin phase accumulation and decay rates around astrocytes and axons show significant deviations from the static dephasing assumption, particularly in regions with restricted/hindered diffusion and high axonal volume fractions.
Impact: The static dephasing assumption, commonly used to model magnetic susceptibility effect within a voxel, may fail in brain microstructure, particularly in regions with restricted/hindered diffusion and high axonal volume fraction, highlighting the necessity of incorporating diffusion effects.
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