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Abstract #3274

The Application of Magnetic Susceptibility Separation for Measuring Cerebral Oxygenation in Preterm Neonates

Thomas Gavin Carmichael1,2, Alexander Rauscher3, Ruth E Grunau2,3, and Alexander Mark Weber2,3
1Integrated Sciences, The University of British Columbia, Vancouver, BC, Canada, 2BC Children's Hospital Research Institute, The University of British Columbia, Vancouver, BC, Canada, 3Pediatrics, The University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Susceptibility/QSM, Oxygenation

Motivation: Accurate and non-invasive methods for measuring cerebral oxygenation are needed to improve neurodevelopmental outcomes in preterm infants.

Goal(s): We aimed to assess whether decomposing quantitative susceptibility mapping (QSM) images into their paramagnetic and diamagnetic components enhanced the accuracy of measuring cerebral venous oxygen saturation (SvO2) in neonates.

Approach: We processed the QSM images of 19 preterm neonates to isolate their paramagnetic components and calculate SvO2 in the central cerebral veins (CCV) and superior sagittal sinus (SSS).

Results: SSS SvO2 values derived from paramagnetic components agreed well with findings from similar studies.

Impact: Magnetic susceptibility separation, an MRI post-processing technique, shows promise as a non-invasive method of measuring regional cerebral oxygenation in neonates, and may serve as tool for clinicians and researchers alike.

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