Keywords: Susceptibility/QSM, Genetic Diseases, Sickle Cell Disease
Motivation: Normal developmental patterns of brain magnetic susceptibility (χ) may be altered in sickle cell anaemia (SCA), potentially affecting cognitive function and contributing to neurological symptoms.
Goal(s): To investigate patterns of χ changes with age in young Tanzanian SCA patients compared to healthy controls.
Approach: Using quantitative susceptibility mapping (QSM), we analyzed both regional deep grey matter and voxelwise χ differences.
Results: χ increased more slowly with age in SCA patients in the caudate and globus pallidus. Lower age and sex-corrected χ values were observed in the globus pallidus and putamen compared to controls.
Impact: Different patterns of age-related susceptibility accumulation observed in some deep grey-matter regions in children with SCA compared to controls motivate efforts to fully characterize changes to susceptibility and other tissue properties across the lifespan, using QSM and other quantitative techniques.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords