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Abstract #3278

Age-Related Patterns of Deep Grey Matter Magnetic Susceptibility in Tanzanian Children with Sickle Cell Anaemia

Mitchel Lee1, Mboka Jakob2, Mohammed Elgwely3,4, Fenella Kirkham5, and Karin Shmueli1
1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Department of Radiology & Imaging, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania, 3Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 4Lyshold Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 5Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

Synopsis

Keywords: Susceptibility/QSM, Genetic Diseases, Sickle Cell Disease

Motivation: Normal developmental patterns of brain magnetic susceptibility (χ) may be altered in sickle cell anaemia (SCA), potentially affecting cognitive function and contributing to neurological symptoms.

Goal(s): To investigate patterns of χ changes with age in young Tanzanian SCA patients compared to healthy controls.

Approach: Using quantitative susceptibility mapping (QSM), we analyzed both regional deep grey matter and voxelwise χ differences.

Results: χ increased more slowly with age in SCA patients in the caudate and globus pallidus. Lower age and sex-corrected χ values were observed in the globus pallidus and putamen compared to controls.

Impact: Different patterns of age-related susceptibility accumulation observed in some deep grey-matter regions in children with SCA compared to controls motivate efforts to fully characterize changes to susceptibility and other tissue properties across the lifespan, using QSM and other quantitative techniques.

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